What can you expect when you take psilocybin mushrooms? Results vary greatly from person to person and the dosage has a huge impact on this. A microdose (250 mg or less) can provide subtle enhancements to your mood, creativity, clarity, and consciousness. A moderate dosage (500-3500 mg) can cause changes to your emotions, visions, thoughts, and perceptions. Most users report a state of reflection, in which they are able to take in thoughts and feelings that they may avoid or not take in on a normal day. Peace and a general connectedness to the world are also quite common. A macrodose (over 5000 mg) can lead to a bad trip. However, for experienced users, a higher dosage may be needed to elicit the same effects over time if tolerance has built up.